micrornas and asthma regulation.
نویسندگان
چکیده
micrornas participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of micrornas in the pathogenesis of asthma. a review of the english medical literatures was conducted by searching pubmed for studies concerning asthma and micrornas. the results of the present study indicate that micrornas play important roles in regulating asthma immune responses. micrornas not only participate in determining dcs phenotype and then naive t lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. furthermore, micrornas are also shown to be targets for asthma therapy in the future.
منابع مشابه
MicroRNAs and Asthma Regulation.
MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. A review of the English medical literatures was conducted by searching PubMed for studies concerning asthma and microRNAs. The results of the present study indicate that microRNAs play important roles in regulating asthma immune res...
متن کاملRegulation of cardiac microRNAs by cardiac microRNAs.
RATIONALE MicroRNAs modestly suppress their direct mRNA targets, and these direct effects are amplified by modulation of gene transcription pathways. Consequently, indirect mRNA modulatory effects of microRNAs to increase or decrease mRNAs greatly outnumber direct target suppressions. Because microRNAs are products of transcription, the potential exists for microRNAs that regulate transcription...
متن کاملBiogenesis and regulation of cardiovascular microRNAs.
MicroRNAs (miRNAs) are important regulators of gene expression and fundamentally impact on cardiovascular function in health and disease. A tight control of miRNA expression is crucial for the maintenance of tissue homeostasis. However, a comprehensive understanding of the various levels of miRNA regulation is in its infancy. We here summarize the current knowledge about regulation of cardiovas...
متن کاملMicroRNAs and the regulation of intestinal homeostasis
The mammalian intestinal tract is a unique site in which a large portion of our immune system and the 10(14) commensal organisms that make up the microbiota reside in intimate contact with each other. Despite the potential for inflammatory immune responses, this complex interface contains host immune cells and epithelial cells interacting with the microbiota in a manner that promotes symbiosis....
متن کاملMicroRNAs: Synthesis, Gene Regulation and Osteoblast Differentiation.
The central dogma of transfer of genetic information from DNA to protein via mRNA is now challenged by small fragment of non coding RNAs typically 19-25 nucleotides in length namely microRNAs (miRNAs). miRNAs regulate expression of the protein coding genes by interfering in their mRNAs and, thus, act as key regulators of diverge cellular activities. Osteoblast differentiation, a key step in ske...
متن کاملNovel Modulators of Asthma and Allergy: Exosomes and MicroRNAs
Intercellular communication is crucial to the immune system response. In the recent years, the discovery of exosomes has changed the way immune response orchestration was understood. Exosomes are able to operate as independent units that act as mediators in both physiological and pathological conditions. These structures contain proteins, lipidic mediators, and nucleic acids and notoriously inc...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of allergy, asthma and immunologyجلد ۱۴، شماره ۲، صفحات ۱۲۰-۱۲۵
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023